The plant Alpinia calcarata has been traditionally used for various diseases and traditionally indicated in the treatment of asthma. Hence, the present study was conducted to evaluate the anti-asthmatic activity of ethanolic extract of Alpinia calcarata rhizome against the goat tracheal smooth muscle contraction in-vitro model. Alpinia calcarata significantly inhibited histamine induced contraction of isolated goat trachea preparation as dose dependent effect indicating its H1 receptor antagonist activity and the primary phytochemical screening revealed the presence of flavanoids, tannins and other constituents. Hence the present study concluded that the ethanolic extract of Alpinia calcarata rhizome possessed a significant (P<0.05) antiasthmatic activity against the histamine induced contraction in goat tracheal chain preparations models respectively.
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